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  DHEA
 
Authors: Alex J. Rai, PhD, Lori J. Sokoll, PhD Last modified: November 29, 2001
DIAGNOSTIC CRITERIA
 
 
IMPORTANT POINTS/RECOMMENDATIONS
  • DHEA is the prinicpal andrenal androgen formed by the adrenal cortex, and is secreted at a rate of 20 mg/day.
  • Glucocorticoid therapy suppresses the secretion of DHEA.
  • DHEA exhibits a circadian rhythm; early morning collection is preferred (before 10:30am). No steroids, ACTH, estradiol, or gonadotropin medications should be given for 48h prior to sample collection.
  • Reference intervals are assay dependent and may vary between laboratories.
 
REFERENCES
  1. Laurence M. Demers and Ronald J. Whitley ;  Adrenocortical Function ;  Tietz Textbook of Clinical Chemistry, Third Edition. W.B. Saunders Company (1999).

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